Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon on the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.
Mason Storm, a 'go it alone' cop, is gunned down at home. The intruders kill his wife, and think they've killed both Mason and his son too. Mason is secretly taken to a hospital where he spends several years in a coma. His son meanwhile is growing up thinking his father is dead. When Mason wakes up, everyone is in danger - himself, his son, his best friend, his nurse - but most of all those who arranged for his death